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Additionally, it stimulates the expression of the HB-EGF gene for epidermal growth factor and ectodomain shedding

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Some people report bloating, fullness, heartburn, or diarrhea

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The peptide also does not stimulate IGF-1 production, avoiding the growth-promoting and potentially mitogenic effects associated with IGF-1 elevation

In view of the GO results, the Kyoto Encyclopedia of Genes and Genomes (KEGG) network enrichment analysis highlighted a greater effect on a metabolic pathway, glutathione metabolism (path:ko00480), which included upregulated Ggt1 and downregulated Anpep, in OVX rats (Figure 2F, and see Supplementary Tables S7)